Pengaruh Kesakitan pada Nefron Terhadap Terjadinya Penyakit Gagal Ginjal
DOI:
https://doi.org/10.55606/sscj-amik.v3i2.5498Keywords:
Nephron Damage, Kidney Failure, Filtration FunctionAbstract
Nephrons are the smallest functional units in the kidneys that are responsible for filtering blood, regulating fluid balance, and excreting waste through urine. When nephrons are damaged or diseased, kidney function can be significantly impaired. Nephron damage is usually caused by various factors, such as hypertension, diabetes, kidney infections, or certain drug toxicity. In the early stages, nephron damage can cause a decrease in glomerular filtration rate (GFR). As a result, metabolic waste products such as urea and creatinine accumulate in the blood, known as azotemia. Over time, progressive damage to the nephrons can trigger chronic kidney disease (CKD). In more severe cases, when most of the nephrons are no longer functioning, the kidneys lose their ability to maintain the body's homeostasis. This results in electrolyte imbalance, metabolic acidosis, and excess fluid buildup, known as end-stage renal disease (ESRD). At this stage, patients require renal replacement therapy such as dialysis or kidney transplantation to survive. Prevention of nephron damage is very important, including through the management of comorbidities such as diabetes and hypertension, adequate fluid intake, and avoiding exposure to toxic substances that damage the kidneys. Thus, the risk of kidney failure can be minimized.
References
Napitupulu, D. S., & Sihombing, R. A. K. (2023). Gambaran kadar kreatinin pada pasien gagal ginjal kronik yang menjalani hemodialisis di Rumah Sakit Elisabeth Medan tahun 2022. Elisabeth Health Jurnal, 8(2), 151–156.
Natassia, K., & Pistanty, M. A. (2020). Efektivitas aromaterapi lavender terhadap penurunan tingkat stres penderita gagal ginjal kronik. The Shine Cahaya Dunia S-1 Keperawatan, 5(1).
Pandiangan, F. D. D. H. (2021). Gambaran kadar hemoglobin pasien gagal ginjal kronik sesudah melakukan hemodialisis. Jurnal Medika Hutama, 2(04), 1040–1046.
Rosana, R. (2023). Hubungan dukungan keluarga dengan nilai interdialytic weight gain (IDWG) pada pasien gagal ginjal kronis yang menjalani hemodialisis di Rumah Sakit Panti Waluya Sawahan Malang (Doctoral dissertation, STIKES Panti Waluya Malang).
Suri, N., Mulyaningsih, D. W., & Melani, D. (2022). Evaluasi permasalahan terkait obat pada pasien gagal ginjal kronik dengan komplikasi hipertensi dan diabetes melitus tipe II di Rumah Sakit Umum Daerah Provinsi Lampung. Jurnal Ilmu Kedokteran dan Kesehatan, 9(3), 1063.
Tribun Jogja. (2022, April 19). Deretan gejala gagal ginjal stadium akhir, menandakan ginjal Anda sudah menyerah.
Udlma, S., Sudarsih, S., & Merbawani, R. (2022). Hubungan spiritual coping dengan tingkat stres pada pasien gagal ginjal kronis yang menjalani hemodialisis di RSUD Dr. Wahidin Sudiro Husodo Kota Mojokerto.
Wati, R. A., & Wahyu, A. (2024). Pengaruh terapi musik klasik terhadap intensitas nyeri insersi AV-Fistula pasien gagal ginjal kronik yang menjalani hemodialisis di Rumah Sakit Murni Teguh Ciledug. Indonesian Trust Nursing Journal, 2(2), 61–67.
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